The big difference is the grease seal inner diameter which basically indicates what spindle it would fit. The part # 8-219-4UC3-EZ has a grease seal with an inner diameter that is 2.125 inch whereas the part # 42866UC3-EZ has that dimension of 2.25 inch.
Also worth noting is that you can swap the grease seal of the # 8-219-4UC3-EZ to the other size with just the part # GS-2250DL. view full answer...